Ionis Pharmaceuticals (IONS) Financials: Revenue & Earnings
IONS$43.960.00 0.00%
$7.31B
Market Cap
-12.55
P/E
109.71
Forward P/E
49
Score
Ionis Pharmaceuticals (IONS) Financials: Revenue & Earnings
IONS price $43.96 0.00 0.00%
- Ticker
- IONS
- Price
- $43.96
- Change
- 0.00 0.00%
- Market cap ?
- $7.31B
- P/E ?
- -12.55
- Forward P/E ?
- 109.71
- Dividend yield ?
- 0.00%
- Beta ?
- 0.38
- Sector
- Healthcare
- Industry
- Biotechnology
- Stocklytics score
- 49
- Value
- 60
- Quality
- 33
- Growth
- 53
Stocklytics score rationale: value 60, quality 33, growth 53.
Financials
| 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|
| 372776000 | 514179000 | 599674000 | 1122599000 | 729264000 | 810456000 | 587367000 | 787647000 | 705138000 | 944000000 |
Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy…
Fair value
IONS fair value $13.01. Price $43.96. Price is 238% above fair value.
Above fair value, and more expensive than usual. A larger premium than on 61% of days in the past 5 years.
Fair value is an estimate of what one share is worth if future cash flows arrive as modeled. It is not a forecast of the share price. How discounted cash flow works.
Calculated with a 10-year free-cash-flow discount. Starting free cash flow 260.21M. Growth 0.00%. When analyst earnings forecasts are available, free cash flow in those years is forecast earnings times the company's usual conversion of earnings into free cash flow, kept between 60% and 130%. Years with fewer than 3 analyst estimates are left out. Growth then fades in a straight line to terminal growth by year 10, starting from the last well-covered year's growth, or from the pace across those years when the final year slows sharply, kept between 0% and 20%. Without those forecasts, year-1 growth is analyst revenue growth for the next full fiscal year, or 5-year historical revenue growth when that forecast is missing, held for five years, then fading in a straight line to terminal growth by year 10. Terminal growth 3.00%. Discount rate 8.70% (beta 0.8). Beta is kept between 0.8 and 2.0, which on its own would make the discount rate 8.7% to 15.3%. The rate is then capped at 12%. A cap is used because a discount above 12% pushes higher-beta stocks further from the price. The discount rate stays at least 5 percentage points above terminal growth. Shares 166.18M. Net debt 2.24B. The earnings value is next-12-months earnings per share, or trailing earnings when that forecast is missing, times the stock's own 10-year median P/E, kept between 8 and 40. Fewer than five years of history uses the sector's typical P/E. Fair value is the average of the cash-flow value and the earnings value when both exist. Model uncertainty is high when fair value is more than 60% from the price, or when most of the cash-flow value sits after year 10.
Model uncertainty high for this stock
Earnings
| Date | EPS actual | EPS estimate | Revenue | Revenue estimate |
|---|---|---|---|---|
| 2026-11-04 | — | -1.22 | — | 181.56M |
| 2026-07-29 | -0.69 | -1.09 | 268.00M | 189.10M |
| 2026-04-29 | -0.56 | -0.85 | 246.00M | 195.56M |
| 2026-02-25 | -1.41 | -1.24 | 203.00M | 156.07M |
| 2025-10-29 | -0.61 | -1.15 | 156.72M | 153.57M |
| 2025-07-30 | 0.86 | 0.27 | 452.05M | 131.75M |
| 2025-04-30 | -0.75 | -1.11 | 131.61M | 150.59M |
| 2025-02-19 | -0.66 | -1.09 | 226.58M | 131.14M |
| 2024-11-06 | -0.95 | -1.16 | 133.81M | 144.44M |
| 2024-08-01 | -0.45 | -0.92 | 225.25M | 150.07M |
| 2024-05-07 | -0.98 | -1.05 | 119.00M | 131.42M |
| 2024-02-21 | -0.06 | -0.83 | 324.50M | 174.76M |
| 2023-11-02 | -1.03 | -1.04 | 144.21M | 132.90M |
| 2023-08-09 | -0.60 | -0.90 | 188.41M | 138.83M |
| 2023-05-03 | -0.87 | -0.91 | 130.52M | 140.51M |
| 2023-02-22 | -0.37 | -1.06 | 151.89M | 160.13M |
| 2022-11-09 | -0.33 | -0.74 | 159.77M | 143.95M |
| 2022-08-09 | -0.74 | -0.62 | 133.79M | 140.54M |
| 2022-05-04 | -0.46 | -0.71 | 141.92M | 122.46M |
| 2022-02-24 | 1.41 | 0.28 | 440.01M | 275.55M |
| 2021-11-03 | -0.58 | -0.53 | 133.09M | 163.67M |
| 2021-08-04 | -0.57 | -0.60 | 125.75M | 126.00M |
| 2021-05-05 | -0.64 | -0.53 | 111.61M | 138.50M |
| 2021-02-24 | -2.44 | 0.24 | 290.28M | 274.45M |
| 2020-11-04 | -0.22 | -0.09 | 160.08M | 65.49M |
| 2020-08-05 | -0.23 | -0.28 | 145.54M | 177.18M |
| 2020-05-06 | -0.10 | -0.11 | 133.37M | 45.73M |
| 2020-02-26 | 1.41 | 0.93 | 493.68M | 358.69M |
| 2019-11-06 | 0.18 | -0.32 | 167.89M | 298.47M |
| 2019-08-07 | -0.01 | -0.27 | 163.81M | 4.42B |
| 2019-05-09 | 0.92 | 0.43 | 297.21M | 282.83M |
| 2019-02-27 | 2.42 | 0.40 | 192.12M | 4.35M |
| 2018-11-06 | -0.03 | -0.16 | 145.40M | 775.44M |
| 2018-08-07 | -0.05 | -0.02 | 117.75M | 36.54M |
| 2018-05-04 | -0.01 | -0.01 | 144.42M | 433.26M |
| 2018-02-27 | 0.02 | -0.08 | 172.30M | 86.15M |
| 2017-11-07 | -0.02 | -0.05 | 118.31M | 200.56M |
| 2017-08-08 | -0.09 | -0.04 | 112.27M | 96.67M |
| 2017-05-09 | 0.03 | -0.10 | 115.80M | 183.84M |
| 2017-02-28 | 0.24 | -0.12 | 160.35M | 91.63M |
Dividends
Yield 0.00%. Payout ratio 0.00%. Frequency —.
Safety score 37/100 · Watch. Payout ratio is 0% of earnings. Free-cash-flow coverage is not available, so this part stays neutral. No dividend history was found. There is no dividend yield.
| Ex-date | Dividend | Record | Payment | Frequency |
|---|---|---|---|---|
| No data yet. | ||||
Insider trades
| Date | Insider | Action | Shares | Price | Value |
|---|---|---|---|---|---|
| 2026-10-16 | Devers Shannon L. | Sell | 1.36K | $43.54 | 59.08K |
| 2026-10-16 | Swayze Eric | Sell | 53 | $43.54 | 2.31K |
| 2026-10-15 | Devers Shannon L. | Sell | 2.82K | — | — |
| 2026-10-15 | Devers Shannon L. | Buy | 2.82K | — | — |
| 2026-10-15 | Swayze Eric | Sell | 125 | — | — |
| 2026-10-15 | Swayze Eric | Buy | 125 | — | — |
| 2026-08-31 | BENNETT C FRANK | Buy | 110 | $51.31 | 5.64K |
| 2026-08-31 | O'NEIL PATRICK R. | Buy | 63 | $51.31 | 3.23K |
| 2026-08-31 | Monia Brett P | Buy | 98 | $51.31 | 5.03K |
| 2026-08-31 | Birchler Brian | Buy | 58 | $51.31 | 2.98K |
| 2026-07-31 | Hayden Michael R | Buy | 5.00K | $51.60 | 258.00K |
| 2026-07-30 | Hayden Michael R | Buy | 15.00K | $53.38 | 800.70K |
| 2026-07-15 | Reikes Peter N | Buy | 3.40K | — | — |
| 2026-07-15 | HANTSON LUDWIG | Buy | 3.40K | — | — |
| 2026-07-15 | HERMAN JOAN E | Buy | 5.22K | — | — |
| 2026-07-15 | HERMAN JOAN E | Sell | 5.22K | — | — |
| 2026-07-15 | BERTHELSEN SPENCER R | Buy | 5.22K | — | — |
| 2026-07-15 | BERTHELSEN SPENCER R | Sell | 5.22K | — | — |
| 2026-07-07 | BENNETT C FRANK | Sell | 5.54K | $83.58 | 462.69K |
| 2026-07-07 | BENNETT C FRANK | Buy | 15.00K | $85.46 | 1.28M |
| 2026-07-07 | BENNETT C FRANK | Sell | 15.00K | $85.46 | 1.28M |
| 2026-07-07 | BENNETT C FRANK | Sell | 15.00K | $85.46 | 1.28M |
| 2026-07-07 | Diaz Allene M. | Buy | 10.11K | $47.11 | 476.33K |
| 2026-07-07 | Diaz Allene M. | Sell | 10.11K | $85.42 | 863.64K |
| 2026-07-07 | Diaz Allene M. | Sell | 10.11K | $47.11 | 476.33K |
| 2026-07-07 | Kordasiewicz Holly B. | Sell | 362 | $84.30 | 30.52K |
| 2026-07-01 | YANG MICHAEL J. | Buy | 2.30K | — | — |
| 2026-07-01 | YANG MICHAEL J. | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | LOSCALZO JOSEPH | Buy | 2.30K | — | — |
| 2026-07-01 | LOSCALZO JOSEPH | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | HERMAN JOAN E | Buy | 2.30K | — | — |
| 2026-07-01 | HERMAN JOAN E | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | KLEIN JOSEPH III | Buy | 11.52K | $39.94 | 460.03K |
| 2026-07-01 | KLEIN JOSEPH III | Sell | 99 | $79.45 | 7.87K |
| 2026-07-01 | KLEIN JOSEPH III | Buy | 2.30K | — | — |
| 2026-07-01 | KLEIN JOSEPH III | Sell | 11.42K | $79.04 | 902.55K |
| 2026-07-01 | KLEIN JOSEPH III | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | KLEIN JOSEPH III | Sell | 11.52K | $39.94 | 460.03K |
| 2026-07-01 | Hayden Michael R | Buy | 2.30K | — | — |
| 2026-07-01 | Hayden Michael R | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | Diaz Allene M. | Buy | 2.30K | — | — |
| 2026-07-01 | Diaz Allene M. | Buy | 5.37K | $79.19 | 425.17K |
| 2026-07-01 | BERTHELSEN SPENCER R | Buy | 2.30K | — | — |
| 2026-07-01 | BERTHELSEN SPENCER R | Buy | 5.37K | $79.19 | 425.17K |
| 2026-06-26 | Baroldi Joseph | Buy | 1.77K | $32.60 | 57.67K |
| 2026-06-26 | Baroldi Joseph | Buy | 3.87K | $56.78 | 219.51K |
| 2026-06-26 | Baroldi Joseph | Sell | 5.63K | $80.16 | 451.70K |
| 2026-06-26 | Baroldi Joseph | Sell | 3.87K | $56.78 | 219.51K |
| 2026-06-26 | Baroldi Joseph | Sell | 1.77K | $32.60 | 57.67K |
| 2026-06-26 | O'NEIL PATRICK R. | Sell | 3.07K | $80.00 | 245.52K |
| 2026-06-26 | Schneider Eugene | Buy | 26.00K | $60.89 | 1.58M |
| 2026-06-26 | Schneider Eugene | Sell | 26.00K | $81.05 | 2.11M |
| 2026-06-26 | Schneider Eugene | Sell | 26.00K | $60.89 | 1.58M |
| 2026-06-26 | Monia Brett P | Buy | 50.00K | $56.78 | 2.84M |
| 2026-06-26 | Monia Brett P | Sell | 50.00K | $80.59 | 4.03M |
| 2026-06-26 | Monia Brett P | Sell | 50.00K | $56.78 | 2.84M |
| 2026-06-25 | Monia Brett P | Buy | 21.07K | $32.60 | 686.95K |
| 2026-06-25 | Monia Brett P | Sell | 21.07K | $78.49 | 1.65M |
| 2026-06-25 | Monia Brett P | Sell | 21.07K | $32.60 | 686.95K |
| 2026-06-25 | Swayze Eric | Sell | 10.60K | $79.18 | 839.49K |
| 2026-06-24 | Monia Brett P | Buy | 14.56K | $32.60 | 474.82K |
| 2026-06-24 | Monia Brett P | Sell | 14.56K | $78.41 | 1.14M |
| 2026-06-24 | Monia Brett P | Sell | 14.56K | $32.60 | 474.82K |
| 2026-06-15 | BERTHELSEN SPENCER R | Buy | 8.00K | $24.42 | 195.36K |
| 2026-06-15 | BERTHELSEN SPENCER R | Sell | 8.00K | $73.49 | 587.92K |
| 2026-06-15 | BERTHELSEN SPENCER R | Sell | 8.00K | $24.42 | 195.36K |
| 2026-06-12 | Kordasiewicz Holly B. | Buy | 19.89K | $56.78 | 1.13M |
| 2026-06-12 | Kordasiewicz Holly B. | Buy | 12.00K | $32.60 | 391.20K |
| 2026-06-12 | Kordasiewicz Holly B. | Buy | 21.00K | $60.89 | 1.28M |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 41.00K | $73.09 | 3.00M |
| 2026-06-12 | Kordasiewicz Holly B. | Buy | 7.95K | $60.89 | 484.14K |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 19.84K | $74.05 | 1.47M |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 7.95K | $60.89 | 484.14K |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 12.00K | $32.60 | 391.20K |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 19.89K | $56.78 | 1.13M |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 21.00K | $60.89 | 1.28M |
| 2026-06-04 | Reikes Peter N | Buy | 10.75K | $75.13 | 807.87K |
| 2026-06-04 | HANTSON LUDWIG | Buy | 10.75K | $75.13 | 807.87K |
| 2026-06-04 | Reikes Peter N | Other | 0 | — | — |
| 2026-06-04 | HANTSON LUDWIG | Other | 0 | — | — |
| 2026-06-01 | BERTHELSEN SPENCER R | Buy | 8.00K | $24.42 | 195.36K |
| 2026-06-01 | BERTHELSEN SPENCER R | Sell | 8.00K | $75.67 | 605.36K |
| 2026-06-01 | BERTHELSEN SPENCER R | Sell | 8.00K | $24.42 | 195.36K |
| 2026-05-14 | Monia Brett P | Buy | 3.22K | $32.60 | 104.97K |
| 2026-05-14 | Monia Brett P | Sell | 3.22K | $78.68 | 253.35K |
| 2026-05-14 | Monia Brett P | Sell | 3.22K | $32.60 | 104.97K |
| 2026-05-13 | Monia Brett P | Buy | 1.32K | $32.60 | 42.90K |
| 2026-05-13 | Monia Brett P | Sell | 1.32K | $78.01 | 102.67K |
| 2026-05-13 | Monia Brett P | Sell | 1.32K | $32.60 | 42.90K |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 16.00K | $64.80 | 1.04M |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 12.00K | $60.20 | 722.40K |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 16.00K | $42.88 | 686.08K |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 10.32K | $41.08 | 423.99K |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 12.00K | $40.05 | 480.60K |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 59.51K | $74.90 | 4.46M |
| 2026-05-04 | LOSCALZO JOSEPH | Buy | 10.97K | $38.06 | 417.44K |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 17.78K | $75.58 | 1.34M |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 10.97K | $38.06 | 417.44K |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 12.00K | $40.05 | 480.60K |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 10.32K | $41.08 | 423.99K |
Institutional holders
Latest filed quarter: Q2 2026.
Institutions holding: 556, holders +29 vs prior quarter. Ownership 109.65%.
| Holder | Shares | Change | Change % | Value |
|---|---|---|---|---|
| FMR LLC | 24.63M | 75.32K | +0.31% | 1.95B |
| CAPITAL WORLD INVESTORS | 21.67M | 482.86K | +2.28% | 1.72B |
| BLACKROCK, INC. | 10.70M | 262.18K | +2.51% | 848.77M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7.86M | 50.63K | +0.65% | 623.18M |
| WELLINGTON MANAGEMENT GROUP LLP | 7.65M | 1.26M | +19.71% | 606.68M |
| VANGUARD CAPITAL MANAGEMENT LLC | 7.21M | 93.17K | +1.31% | 571.80M |
| TWO SIGMA INVESTMENTS, LP | 6.25M | 394.71K | +6.74% | 495.75M |
| ROYAL BANK OF CANADA | 6.18M | 2.38M | +62.62% | 490.21M |
| STATE STREET CORP | 4.33M | 339.28K | +8.49% | 343.71M |
| T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 3.96M | -2.20M | -35.71% | 313.94M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.58M | -400.31K | -10.05% | 294.75M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.18M | 159.25K | +5.26% | 252.50M |
| JPMORGAN CHASE & CO | 2.67M | 308.15K | +13.04% | 216.20M |
| ARTISAN PARTNERS LIMITED PARTNERSHIP | 2.64M | 581.72K | +28.26% | 209.33M |
| TWEEDY, BROWNE CO LLC | 2.28M | 4.69K | +0.21% | 180.81M |
| DEEP TRACK CAPITAL, LP | 2.20M | 250.00K | +12.82% | 174.44M |
| GOLDMAN SACHS GROUP INC | 2.11M | 410.10K | +24.13% | 167.30M |
| BAKER BROS. ADVISORS LP | 2.05M | 0 | 0.00% | 162.36M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.98M | 0 | 0.00% | 156.97M |
| AMERICAN CENTURY COMPANIES INC | 1.95M | 283.27K | +17.03% | 154.38M |
| FRANKLIN TEMPLETON INC | 1.62M | 48.35K | +3.07% | 128.72M |
| SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P. | 1.61M | 1.61M | New | 127.26M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.61M | 21.79K | +1.38% | 127.26M |
| BARCLAYS PLC | 1.60M | 1.31M | +453.05% | 127.11M |
| PICTET ASSET MANAGEMENT HOLDING SA | 1.60M | 162.00K | +11.29% | 126.98M |
Earnings and financials
Ionis Pharmaceuticals, Inc. (IONS) trades at $43.96, with a market cap of $7.31B and a trailing P/E of -12.55. Revenue below is the annual history on file. It describes what the business has already reported. It is not a forecast and it is not a recommendation.
Financials
| 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|
| 372776000 | 514179000 | 599674000 | 1122599000 | 729264000 | 810456000 | 587367000 | 787647000 | 705138000 | 944000000 |
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