Septerna (SEPN) Stock Insights

SEPN price $44.25 +0.11 +0.25%

Ticker
SEPN
Price
$44.25
Change
+0.11 +0.25%
Market cap ?
$2.07B
P/E ?
-75.39
Dividend yield ?
0.00%
Beta ?
2.28
Sector
Healthcare
Industry
Biotechnology
Stocklytics score
64
Value
55
Quality
64
Growth
73

Stocklytics score rationale: value 55, quality 64, growth 73.

Financials

202320242025
151000107500045951000

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric…

Fair value

SEPN fair value Not meaningful. Price $44.25.

Fair value is an estimate of what one share is worth if future cash flows arrive as modeled. It is not a forecast of the share price. How discounted cash flow works.

Not meaningful. The model is more than 80% below the live price, which happens for unprofitable or very early companies and is not a price target.

Compare SEPN

Earnings

DateEPS actualEPS estimateRevenueRevenue estimate
2026-11-09—-0.41—20.78M
2026-08-10-0.29-0.4326.75M19.22M
2026-05-12-0.19-0.5126.52M16.98M
2026-03-09-0.24-0.2324.12M18.20M
2025-11-10-0.090.1921.50M17.27M
2025-08-11-0.56-0.05119.00K5.00M
2025-05-15-0.49-0.38219.00K30.00M
2025-03-27-0.64-0.69212.00K—
2024-11-21-8.40-0.83176.00K—
2024-11-07————
2023-12-312.05—118.00K—
2023-09-30-0.56—33.00K—

Dividends

Yield 0.00%. Payout ratio 0.00%. Frequency —.

Safety score 37/100 · Watch. Payout ratio is 0% of earnings. Free-cash-flow coverage is not available, so this part stays neutral. No dividend history was found. There is no dividend yield.

Ex-dateDividendRecordPaymentFrequency
No data yet.

Insider trades

DateInsiderActionSharesPriceValue
2026-10-15Bhatt ElizabethBuy4.00K$6.8127.24K
2026-10-15Bhatt ElizabethSell1.09K$36.8740.34K
2026-10-15Bhatt ElizabethSell2.91K$37.61109.31K
2026-10-15Bhatt ElizabethSell4.00K$6.8127.24K
2026-09-08Patni RajivBuy275.00K$37.3710.28M
2026-09-01Long Daniel D.Buy3.33K$2.769.20K
2026-09-01Long Daniel D.Sell3.33K$37.83126.08K
2026-09-01Long Daniel D.Sell3.33K$2.769.20K
2026-08-24Patni RajivOther0——
2026-08-12Third Rock Ventures V, L.P.Buy147.06K$50.277.39M
2026-08-12Third Rock Ventures V, L.P.Buy141$51.087.20K
2026-08-12RA CAPITAL MANAGEMENT, L.P.Sell746.50K$42.5031.73M
2026-08-12RA CAPITAL MANAGEMENT, L.P.Sell746.50K$42.5031.73M
2026-08-11Bhatt ElizabethBuy6.32K$2.7617.44K
2026-08-11Bhatt ElizabethBuy18.68K$6.81127.22K
2026-08-11Bhatt ElizabethSell25.00K$44.001.10M
2026-08-11Bhatt ElizabethSell6.32K$2.7617.44K
2026-08-11Bhatt ElizabethSell18.68K$6.81127.22K
2026-08-03Long Daniel D.Buy1.52K$2.764.19K
2026-08-03Long Daniel D.Sell1.00K$33.9833.98K
2026-08-03Long Daniel D.Buy1.82K$2.765.01K
2026-08-03Long Daniel D.Sell2.33K$34.6880.94K
2026-08-03Long Daniel D.Sell1.52K$2.764.19K
2026-08-03Long Daniel D.Sell1.82K$2.765.01K
2026-07-15Bhatt ElizabethBuy4.00K$6.8127.24K
2026-07-15Bhatt ElizabethSell4.00K$33.99135.97K
2026-07-15Bhatt ElizabethSell4.00K$6.8127.24K
2026-07-01Long Daniel D.Buy3.33K$2.769.20K
2026-07-01Long Daniel D.Sell2.10K$34.1071.60K
2026-07-01Long Daniel D.Sell1.23K$34.8142.93K
2026-07-01Long Daniel D.Sell3.33K$2.769.20K
2026-06-29Shaikhly SamiraSell2.18K$6.8114.83K
2026-06-29Shaikhly SamiraBuy2.18K$6.8114.83K
2026-06-29Shaikhly SamiraSell2.18K$35.1876.62K
2026-06-26RA CAPITAL MANAGEMENT, L.P.Buy15.00K$37.34560.10K
2026-06-26Bassan AbrahamBuy15.00K$37.34560.10K
2026-06-26Sharp ShaliniBuy15.00K$37.34560.10K
2026-06-26Coulie BernardBuy15.00K$37.34560.10K
2026-06-26Tong Jeffrey KBuy15.00K$37.34560.10K
2026-06-26Gottesdiener Keith MichaelBuy11.26K$37.34420.45K
2026-06-26Ezekowitz AlanBuy15.00K$37.34560.10K
2026-06-26Simson JakeBuy15.00K$37.34560.10K
2026-06-22Long Daniel D.Buy4.47K$11.7052.31K
2026-06-22Long Daniel D.Buy10.53K$2.7629.06K
2026-06-22Long Daniel D.Sell8.00K$35.10280.80K
2026-06-22Long Daniel D.Sell7.00K$35.97251.78K
2026-06-22Long Daniel D.Sell4.47K$11.7052.31K
2026-06-22Long Daniel D.Sell10.53K$2.7629.06K
2026-06-12Shaikhly SamiraSell6.25K$11.7073.12K
2026-06-12Shaikhly SamiraBuy6.25K$11.7073.12K
2026-06-12Shaikhly SamiraSell6.25K$35.08219.22K
2026-06-01Shaikhly SamiraSell4.36K$1.556.75K
2026-06-01Shaikhly SamiraBuy637$2.761.76K
2026-06-01Shaikhly SamiraBuy943$2.762.60K
2026-06-01Shaikhly SamiraBuy4.36K$1.556.75K
2026-06-01Shaikhly SamiraSell1.70K$27.7847.23K
2026-06-01Shaikhly SamiraSell637$2.761.76K
2026-06-01Shaikhly SamiraSell1.35K$28.7938.76K
2026-06-01Shaikhly SamiraSell943$2.762.60K
2026-06-01Shaikhly SamiraSell2.89K$29.6685.70K
2026-05-26Shaikhly SamiraSell11.80K$6.8180.34K
2026-05-26Shaikhly SamiraBuy11.80K$6.8180.34K
2026-05-26Shaikhly SamiraSell11.80K$30.06354.66K
2026-04-15Bhatt ElizabethBuy4.00K$6.8127.24K
2026-04-15Bhatt ElizabethSell2.57K$23.7661.12K
2026-04-15Bhatt ElizabethSell1.10K$25.2427.79K
2026-04-15Bhatt ElizabethSell326$25.868.43K
2026-04-15Bhatt ElizabethSell4.00K$6.8127.24K
2026-03-02Shaikhly SamiraBuy5.10K$2.7614.08K
2026-03-02Shaikhly SamiraSell4.09K$27.51112.50K
2026-03-02Shaikhly SamiraBuy11.64K$2.7632.12K
2026-03-02Shaikhly SamiraBuy53.71K$1.5583.26K
2026-03-02Shaikhly SamiraSell53.71K$1.5583.26K
2026-03-02Shaikhly SamiraSell5.10K$2.7614.08K
2026-03-02Shaikhly SamiraSell11.64K$2.7632.12K
2026-03-02Shaikhly SamiraSell66.36K$28.141.87M
2026-02-18Bhatt ElizabethBuy4.00K$6.8127.24K
2026-02-18Bhatt ElizabethSell2.20K$28.4662.61K
2026-02-18Bhatt ElizabethSell1.80K$29.5853.25K
2026-02-18Bhatt ElizabethSell4.00K$6.8127.24K
2026-02-06Long Daniel D.Buy80.00K$25.412.03M
2026-02-06Klein UweBuy80.00K$25.412.03M
2026-02-06Shaikhly SamiraBuy80.00K$25.412.03M
2026-02-06Labrucherie Gil MBuy125.00K$25.413.18M
2026-02-06Kim Jae B.Buy125.00K$25.413.18M
2026-02-06Bhatt ElizabethBuy155.00K$25.413.94M
2026-02-06Finer JeffreyBuy400.00K$25.4110.16M
2026-02-06Wilson Mark AndrewBuy165.00K$25.414.19M
2026-01-05Wilson Mark AndrewOther0——
2025-11-10Long Daniel D.Sell3.50K$18.0663.22K
2025-09-25Gottesdiener Keith MichaelBuy33.25K$16.75556.87K
2025-09-25Gottesdiener Keith MichaelOther0——
2025-08-18Klein UweSell7.62K$6.8151.90K
2025-08-18Klein UweBuy7.62K$6.8151.90K
2025-08-18Klein UweBuy4.93K$2.7613.62K
2025-08-18Klein UweSell10.45K$2.7628.85K
2025-08-18Klein UweBuy10.45K$2.7628.85K
2025-08-18Klein UweSell4.93K$2.7613.62K
2025-08-07Shaikhly SamiraBuy30.00K$11.70351.00K
2025-08-07Bhatt ElizabethBuy95.00K$11.701.11M

Institutional holders

Latest filed quarter: Q2 2026.

Institutions holding: 166, holders +41 vs prior quarter. Ownership 105.31%.

HolderSharesChangeChange %Value
RA CAPITAL MANAGEMENT, L.P.7.00M00.00%234.29M
TRV GP V, LLC6.22M00.00%208.16M
DRIEHAUS CAPITAL MANAGEMENT LLC4.43M37.49K+0.85%148.46M
TRV GP VI, LLC4.21M00.00%141.05M
SAMSARA BIOCAPITAL, LLC3.15M00.00%105.46M
GOLDMAN SACHS GROUP INC3.06M156.34K+5.38%102.57M
BLACKROCK, INC.1.93M109.91K+6.03%64.71M
SIREN, L.L.C.1.90M-100.00K-5.00%63.63M
AVORO CAPITAL ADVISORS LLC1.34M00.00%44.79M
JUPITER TOPCO LLC1.31M1.31MNew43.72M
VANGUARD CAPITAL MANAGEMENT LLC1.22M24.71K+2.06%40.91M
PRIMECAP MANAGEMENT CO/CA/1.17M118.55K+11.30%39.10M
FIRST LIGHT ASSET MANAGEMENT, LLC963.26K230.40K+31.44%32.26M
ADAR1 CAPITAL MANAGEMENT, LLC940.75K-149.07K-13.68%31.51M
GEODE CAPITAL MANAGEMENT, LLC679.16K34.02K+5.27%22.75M
STATE STREET CORP652.63K21.18K+3.35%21.86M
LOOMIS SAYLES & CO L P624.75K624.75KNew20.92M
CASDIN CAPITAL, LLC553.27K00.00%18.53M
CATALIO CAPITAL MANAGEMENT, LP536.15K241.79K+82.14%17.96M
CAPTION MANAGEMENT, LLC440.00K440.00KNew14.74M
ALGERT GLOBAL LLC397.49K376.45K+1789.65%13.31M
BALYASNY ASSET MANAGEMENT L.P.350.44K113.76K+48.07%11.74M
LONGAEVA PARTNERS L.P.298.17K223.60K+299.87%9.99M
SOLEUS CAPITAL MANAGEMENT, L.P.275.00K00.00%9.21M
SUSQUEHANNA INTERNATIONAL GROUP, LLP262.00K189.00K+258.90%8.77M

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Septerna (SEPN) Stock Insights

SEPN$44.25+0.11 +0.25%

$2.07B

Market Cap

-75.39

P/E

—

Forward P/E

64

Score

Price History