Spyre Therapeutics (SYRE) Stock Insights

SYRE price $98.54 -0.51 -0.51%

Ticker
SYRE
Price
$98.54
Change
-0.51 -0.51%
Market cap ?
$9.09B
P/E ?
-47.65
Dividend yield ?
0.00%
Beta ?
3.11
Sector
Healthcare
Industry
Biotechnology
Stocklytics score
48
Value
44
Quality
36
Growth
64

Stocklytics score rationale: value 44, quality 36, growth 64.

Financials

2016201720182019202020212022202320242025
4628000520500038880000018739000232900088600000

Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both…

Fair value

SYRE fair value Not meaningful. Price $98.54.

Fair value is an estimate of what one share is worth if future cash flows arrive as modeled. It is not a forecast of the share price. How discounted cash flow works.

Not meaningful

Compare SYRE

Earnings

DateEPS actualEPS estimateRevenueRevenue estimate
2026-11-03—-0.78——
2026-08-04-0.36-0.76——
2026-05-05-0.74-0.66——
2026-02-19-0.70-0.6690.49M142.86M
2025-11-04-0.15-0.76—2.00M
2025-08-05-0.49-0.73——
2025-05-08-0.74-0.84—4.00M
2025-02-28-0.81-0.89—3.00M
2024-11-07-1.36-0.80—2.62M
2024-08-07-0.86-0.90—6.67M
2024-05-09-1.20-0.90——
2024-02-29-4.05-0.48—371.33K
2023-11-09-9.34-0.84—198.00K
2023-08-11-0.57-0.03688.00K198.00K
2023-05-11-5.00-4.50198.00K184.00K
2023-03-02-5.00-5.71168.00K133.33K
2022-11-03-4.33-6.25174.00K208.33K
2022-08-04-6.75-7.95625.00K709.50K
2022-05-05-9.25-8.541.36M1.59M

Dividends

Yield 0.00%. Payout ratio 0.00%. Frequency —.

Safety score 37/100 · Watch. Payout ratio is 0% of earnings. Free-cash-flow coverage is not available, so this part stays neutral. No dividend history was found. There is no dividend yield.

Ex-dateDividendRecordPaymentFrequency
No data yet.

Insider trades

DateInsiderActionSharesPriceValue
2026-10-01King-Jones HeidySell28.93K$14.50419.53K
2026-10-01King-Jones HeidyBuy28.93K$14.50419.53K
2026-10-01King-Jones HeidySell400$89.2435.70K
2026-10-01King-Jones HeidySell16.61K$90.351.50M
2026-10-01King-Jones HeidySell7.23K$91.35660.28K
2026-10-01King-Jones HeidySell2.10K$92.70194.67K
2026-10-01King-Jones HeidySell2.60K$93.46243.00K
2026-10-01Turtle CameronSell600$89.1453.48K
2026-10-01Turtle CameronSell2.68K$90.10241.74K
2026-10-01Turtle CameronSell2.64K$91.49241.35K
2026-10-01Turtle CameronSell3.99K$92.31368.22K
2026-10-01Turtle CameronSell4.99K$93.37465.92K
2026-10-01Turtle CameronSell100$93.919.39K
2026-10-01Burrows Scott LSell7.50K$14.50108.75K
2026-10-01Burrows Scott LBuy7.50K$14.50108.75K
2026-10-01Burrows Scott LSell600$89.0753.44K
2026-10-01Burrows Scott LSell1.50K$90.27135.41K
2026-10-01Burrows Scott LSell2.10K$91.92193.03K
2026-10-01Burrows Scott LSell3.07K$92.95285.45K
2026-10-01Burrows Scott LSell229$93.5721.43K
2026-09-30Burrows Scott LSell17.50K$14.50253.75K
2026-09-30Burrows Scott LBuy17.50K$14.50253.75K
2026-09-30Burrows Scott LSell17.50K$89.891.57M
2026-09-02King-Jones HeidySell400$14.505.80K
2026-09-02King-Jones HeidyBuy400$14.505.80K
2026-09-02King-Jones HeidySell400$90.0036.00K
2026-09-02Burrows Scott LSell18.23K$89.351.63M
2026-09-01King-Jones HeidySell28.00K$14.50405.99K
2026-09-01King-Jones HeidyBuy28.00K$14.50405.99K
2026-09-01King-Jones HeidySell4.84K$86.40418.61K
2026-09-01King-Jones HeidySell16.55K$87.201.44M
2026-09-01King-Jones HeidySell6.21K$88.17547.18K
2026-09-01King-Jones HeidySell400$89.3835.75K
2026-09-01Burrows Scott LSell7.50K$14.50108.75K
2026-09-01Burrows Scott LBuy7.50K$14.50108.75K
2026-09-01Burrows Scott LSell900$86.2577.62K
2026-09-01Burrows Scott LSell4.38K$87.11381.89K
2026-09-01Burrows Scott LSell2.02K$88.03177.47K
2026-09-01Burrows Scott LSell200$89.0417.81K
2026-09-01Turtle CameronSell2.50K$86.36215.90K
2026-09-01Turtle CameronSell8.40K$87.15732.06K
2026-09-01Turtle CameronSell3.70K$88.06325.82K
2026-09-01Turtle CameronSell400$89.0735.63K
2026-08-07Albers Jeffrey W.Sell5.00K$10.3951.95K
2026-08-07Albers Jeffrey W.Sell8.00K$104.38835.04K
2026-08-07Albers Jeffrey W.Sell10.00K$104.681.05M
2026-08-07Albers Jeffrey W.Buy5.00K$10.3951.95K
2026-08-07Albers Jeffrey W.Sell5.00K$104.47522.35K
2026-08-03Burrows Scott LSell7.50K$14.50108.75K
2026-08-03Burrows Scott LBuy7.50K$14.50108.75K
2026-08-03Burrows Scott LSell5.10K$95.21485.57K
2026-08-03Burrows Scott LSell2.30K$96.30221.49K
2026-08-03Burrows Scott LSell100$97.109.71K
2026-08-03Turtle CameronSell800$93.9775.18K
2026-08-03Turtle CameronSell7.16K$95.10680.63K
2026-08-03Turtle CameronSell5.63K$95.93540.57K
2026-08-03Turtle CameronSell1.39K$96.82134.77K
2026-08-03Turtle CameronSell16$97.461.56K
2026-07-01Burrows Scott LSell7.50K$14.50108.75K
2026-07-01Burrows Scott LBuy7.50K$14.50108.75K
2026-07-01Burrows Scott LSell5.78K$87.55505.60K
2026-07-01Burrows Scott LSell1.73K$88.37152.44K
2026-07-01Sloan SheldonSell8.33K$27.46228.85K
2026-07-01Sloan SheldonBuy8.33K$27.46228.85K
2026-07-01Sloan SheldonSell6.50K$87.52568.88K
2026-07-01Sloan SheldonSell1.83K$88.34162.02K
2026-07-01Turtle CameronSell10.18K$87.44889.79K
2026-07-01Turtle CameronSell4.23K$88.12373.10K
2026-07-01Turtle CameronSell590$88.9152.46K
2026-06-25Burrows Scott LSell15.00K$14.50217.50K
2026-06-25Burrows Scott LBuy15.00K$14.50217.50K
2026-06-25Burrows Scott LSell5.00K$87.12435.60K
2026-06-25Burrows Scott LSell10.00K$87.14871.40K
2026-06-23Fairmount Funds Management LLCBuy666.68K——
2026-06-23Fairmount Funds Management LLCSell4.68M$85.31399.66M
2026-06-23Fairmount Funds Management LLCSell16.67K——
2026-06-22HENDERSON MICHAEL THOMASSell20.00K$100.002.00M
2026-06-03Sloan SheldonSell8.33K$27.46228.82K
2026-06-03Sloan SheldonBuy8.33K$27.46228.82K
2026-06-03Sloan SheldonSell8.33K$75.00624.98K
2026-06-01Turtle CameronSell3.56K$69.40246.86K
2026-06-01Turtle CameronSell8.15K$70.50574.50K
2026-06-01Turtle CameronSell3.29K$71.38235.13K
2026-06-01Burrows Scott LSell7.50K$14.50108.75K
2026-06-01Burrows Scott LBuy7.50K$14.50108.75K
2026-06-01Burrows Scott LSell1.80K$69.75125.62K
2026-06-01Burrows Scott LSell2.60K$70.77183.93K
2026-06-01Burrows Scott LSell3.10K$72.06223.39K
2026-05-27Fairmount Funds Management LLCBuy8.03K$72.51581.97K
2026-05-27Albers Jeffrey W.Buy8.03K$72.51581.97K
2026-05-27HENDERSON MICHAEL THOMASBuy8.03K$72.51581.97K
2026-05-27Stelzer LaurieBuy8.03K$72.51581.97K
2026-05-27McKenna Mark C.Buy8.03K$72.51581.97K
2026-05-27Milligan SandraBuy8.03K$72.51581.97K
2026-05-08HENDERSON MICHAEL THOMASSell2.40K$72.57174.46K
2026-05-08HENDERSON MICHAEL THOMASSell33.51K$73.722.47M
2026-05-08HENDERSON MICHAEL THOMASSell24.81K$74.761.86M
2026-05-08HENDERSON MICHAEL THOMASSell19.27K$75.351.45M
2026-05-01Burrows Scott LSell12.50K$14.50181.25K
2026-05-01Burrows Scott LBuy12.50K$14.50181.25K

Institutional holders

Latest filed quarter: Q2 2026.

Institutions holding: 276, holders +75 vs prior quarter. Ownership 113.87%.

HolderSharesChangeChange %Value
FMR LLC13.03M1.25M+10.57%1.16B
BLACKROCK, INC.6.51M985.38K+17.85%577.66M
PERCEPTIVE ADVISORS LLC4.32M536.27K+14.17%383.48M
RTW INVESTMENTS, LP4.25M80.00K+1.92%377.49M
PARADIGM BIOCAPITAL ADVISORS LP3.84M1.88M+96.23%340.98M
VANGUARD CAPITAL MANAGEMENT LLC3.45M391.28K+12.80%306.17M
STATE STREET CORP3.06M450.38K+17.28%271.44M
VENROCK ADVISER, LLC2.99M-700.00K-18.99%265.05M
PRICE T ROWE ASSOCIATES INC /MD/2.96M1.36M+85.20%262.87M
DRIEHAUS CAPITAL MANAGEMENT LLC2.80M8.38K+0.30%248.51M
GEODE CAPITAL MANAGEMENT, LLC2.56M841.35K+48.89%239.26M
VANGUARD PORTFOLIO MANAGEMENT LLC2.33M1.74M+298.22%206.87M
CAPITAL WORLD INVESTORS2.32M1.65M+247.39%205.57M
JUPITER TOPCO LLC2.21M2.21MNew195.88M
TCG CROSSOVER MANAGEMENT, LLC1.90M00.00%168.73M
TANG CAPITAL MANAGEMENT LLC1.89M00.00%167.99M
BANK OF AMERICA CORP /DE/1.78M549.76K+44.77%157.84M
ADAGE CAPITAL PARTNERS GP, L.L.C.1.72M1.72MNew152.91M
WELLINGTON MANAGEMENT GROUP LLP1.58M-243.31K-13.33%140.41M
GOLDMAN SACHS GROUP INC1.48M1.21M+447.55%131.22M
FRANKLIN TEMPLETON INC1.47M590.11K+66.84%130.77M
REMEDIUM CAPITAL PARTNERS, LLC1.46M7.94K+0.55%129.99M
AFFINITY ASSET ADVISORS, LLC1.28M00.00%113.56M
JPMORGAN CHASE & CO1.09M113.73K+11.61%98.87M
HOLOCENE ADVISORS, LP1.02M1.02MNew90.13M

Insights

Revenue by product
PeriodValue
FY2023License: 0.0

Insights · Dividends · Forecast · Financials · Learn

Stocklytics home · Screener

Spyre Therapeutics (SYRE) Stock Insights

SYRE$98.54-0.51 -0.51%

$9.09B

Market Cap

-47.65

P/E

—

Forward P/E

48

Score

Price History